C1 Inhibitor-Mediated Protection from Sepsis

C 1 Inhibitor - Mediated Protection from Sepsis 1

N-linked glycosylation is required for c1 inhibitor-mediated protection from endotoxin shock in mice.

C1 inhibitor (C1INH) prevents endotoxin shock in mice via a direct interaction with lipopolysaccharide (LPS). This interaction requires the heavily glycosylated amino-terminal domain of C1INH. C1INH in which N-linked carbohydrate was removed by using N-glycosidase F was markedly less effective in protecting mice from LPS-induced lethal septic shock. N-deglycosylated C1INH also failed to suppres...

of June 14 , 2017 . This information is current as C 1 Inhibitor - Mediated Protection from Sepsis

Proteolytic inactivation of plasma C1- inhibitor in sepsis.

Activation of both the complement system and the contact system of intrinsic coagulation is implicated in the pathophysiology of sepsis. Because C1 inhibitor (C1-Inh) regulates the activation of both cascade systems, we studied the characteristics of plasma C1-Inh in 48 patients with severe sepsis on admission to the Intensive Care Unit at the Free University of Amsterdam. The ratio between the...

C1-esterase inhibitor concentrate rescues erythrocytes from complement-mediated destruction in autoimmune hemolytic anemia.

In autoimmune hemolytic anemia (AIHA), autoantibody-mediated complement activation results in C3 deposition on RBCs and possibly the formation of the membrane attack complex cumulating in intravascular hemolysis.1-4 In case of acute signs of tissue hypoxia, life-saving transfusion with RBC units is required. However, recovery of RBC transfusions is inadequate because autoantibodies react with r...